Napsin A antibody is a pepsin-like aspartic proteinase. It is expressed in type II pneumocytes and in adenocarcinomas of the lung and kidney. The use of a rabbit monoclonal antibody may be more sensitive than a mouse monoclonal while eliminating the lot-to-lot variability common in polyclonals. Studies have shown that Napsin A is both a more sensitive and specific marker than TTF-1 and is extremely specific for lung adenocarcinomas. Most studies show Napsin A is 100% specific for lung adenocarcinoma vs. lung squamous cell carcinoma.
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