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Napsin A (P), 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Napsin A or Napsin A (RM), catalog numbers PP434 or ACI3043, API3043 as a substitute.
Napsin A antibody is a pepsin-like aspartic proteinase. It is expressed in type II pneumocytes and in adenocarcinomas of the lung and kidney. The use of a rabbit monoclonal antibody may be more sensitive than a mouse monoclonal while eliminating the lot-to-lot variability common in polyclonals. Studies have shown that Napsin A is both a more sensitive and specific marker than TTF-1 and is extremely specific for lung adenocarcinomas. Most studies show Napsin A is 100% specific for lung adenocarcinoma vs. lung squamous cell carcinoma.
1. Bishop JA, Sharma R, Illei PB. Napsin A and thyroid transcription factor-1
expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and
malignant mesothelioma. Hum Pathol. 2010 Jan; 41(1):20-5.
2. Tacha D, et al. A 6-antibody panel for the classification of lung adenocarcinoma
versus squamous cell carcinoma. Appl Immunohistochem Mol Morphol. 2012 May;20 (3):201-7. 3. Tacha D, Yu C, Haas T. TTF-1, Napsin A, p63, TRIM29, Desmoglein-3 and CK5: An Evaluation of Sensitivity and Specificity and Correlation of Tumor Grade for Lung Adenocarcinoma versus Squamous Cell Carcinoma. Mod Pathol. 2011 Feb; 24 (Supplement 1s):425A. 4. Tacha D, Zhou D, Henshall-Powell RL. Distinguishing Adenocarcinoma from Squamous Cell Carcinoma in the Lung Using Multiplex IHC Stains: p63 + CK5 and TTF-1 + Napsin A. Mod Pathol. 2010 Feb; 23(Supplement 1s):414A. 5. Brown AF, et al. Tissue-Preserving Antibody Cocktails to Differentiate Primary Squamous Cell Carcinoma, Adenocarcinoma, and Small Cell Carcinoma of Lung. Arch Pathol Lab Med. 2013 Jan 4. [Epub ahead of print] 6. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”7. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.Page