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Thyroid transcription factor-1 (TTF-1) is a member of the NKX2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate and adrenal glands are not reactive. TTF-1 is detected in primary lung adenocarcinomas and small cell carcinomas. It is absent in mesotheliomas, colon cancer and breast cancer. TTF-1 can be very useful when used in a panel with CK7, CK20, CDX2, Villin and CA125 antibodies.

Intended Use


Species Reactivity



Mouse Monoclonal






TTF-1 (Thyroid transcription factor-1)



Positive Control

Lung adenocarcinoma or thyroid

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and adenocarcinomas of the lung. Cancer Lett 1998 Feb 13;124(1):73-78.
2. Di Loreto C, et al. Immunocytochemical expression of tissue specific transcription
factor-1 in lung carcinoma. J Clin Pathol 1997 Jan;50(1):30-32.
3. Stahlman MT, Gray ME, Whitsett JA. Expression of thyroid transcription factor-1
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Azide Salts.”
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workers from occupationally Acquired Infections; Approved guideline-Third Edition
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