Napsin A mouse antibody is expressed in type II pneumocytes and adenocarcinomas of the lung and kidney. Studies have shown Napsin A to be superior to TTF-1 in sensitivity (87% vs. 64%) with a higher specificity (94.3% vs. 76.1%) for primary non-small cell lung adenocarcinoma. Napsin A is positive in some renal cell carcinomas and shows low expression in other neoplastic tissues such as ovarian cancers with different staining patterns than primary lung cancer (granular cytoplasmic staining). In studies comparing Napsin A and SP-A, Napsin A stained more tumor cells and a higher percentage of lung adenocarcinomas.
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