α-Methylacyl coenzyme A racemase (AMACR antibody), also known as P504S, is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β-oxidation of branched chain fatty acids. In immunohistochemistry (IHC), AMACR antibody has been shown to be a specific marker of prostatic adenocarcinoma. Additionally, prostate glands involved in PIN have been found to express AMACR, where as AMACR was nearly undetectable in benign glands. AMACR (RM) antibody stains the majority of prostate cancer; however, AMACR has been shown to stain many other types of carcinomas such as but not limited to hepatomas, breast carcinomas, pancreatic and islet tumors.
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