Immunotherapy Markers

Immunotherapy Markers Recognize Your Targets to Destroy Tumor Cells

Breast cancer stained with PD-1 antibody

PD-1


• Programmed cell death 1 1

• Expressed on activated and exhausted T lymphocytes 1

• Immune checkpoint marker in tumor immunotherapy 2

PD-L1 in Melanoma

PD-L1


• Immune checkpoint marker in tumor immunotherapy 2

• Binds PD-1 and expressed on immune cells and tumors 2

• Binds to PD-1 to inhibit T-cell receptor signaling & activation 2

(L) Colon cancer stained with FOXP3, (R) Melanoma stained with FOXP3

FOXP3


• Marks T-regulatory cells 2

• Expressed on tumor infiltrating lymphocytes (TILs) 2

• FOXP3+ Tregs correlate with worse prognosis 3

CD8 + Pan Melanoma Cocktail Straining Melanoma

CD8 + Pan Melanoma Cocktail


• Labels T-cytotoxic cells2 2

• Recognizes tumor antigens 2

• Targeted weapons that destroy tumor cells 3

References:
1. Keir, ME. et al. Annu Rev Immunol 2008; 26:677-704
2. Mahoney KM, et al. Nat. Rev. Drug Discovery 2015;14:561-84
3. Vossallo J. et al. Tumor Biol 2015;36:2509-16