CD163 is useful in identifying cells of monocyte/macrophage lineage in normal and neoplastic conditions (1,2). This antibody reacts with human scavenger receptor cysteine-rich protein CD163 (p155, M130) found on mononuclear phagocytes including human monocytes and macrophages (1). Compared with the CD68 antibodies, studies have shown that CD163 demonstrated greater specificity as a marker of disorders of monocyte/macrophage origin (2). However, immunohistochemical evaluation of CD163 expression does not seem to be a sensitive means of determining monocytic differentiation of AMLs or myeloid sarcoma (3).
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1. Lee CH, et al. Clin Cancer Res. 2008 Mar 1; 14(5):1423-30.
2. Lau SK, Chu PG, Weiss LM. Am J Clin Pathol. 2004 Nov; 122(5):794-801.
3. Nguyen TT, et al. Am J Surg Pathol. 2005 May; 29(5):617-24.