CD103 (RM)

Product Description

The Biocare CD103 [EP206] antibody detects the integrin subunit CD103, a cell surface antigen characteristically expressed in hairy cell leukemia (HCL), a Bcell lymphoproliferative disorder.^15,17 CD103 [EP206] has demonstrated reactivity in formalin-fixed paraffinembedded (FFPE) tissue, eliminating the need for flow cytometry or frozen section IHC and making it a valuable component of an IHC panel for HCL diagnosis.¹⁵ Other antibodies commonly used in conjunction with CD103 for HCL detection include CD25, TIA-1, DBA44, and CD11c.^16,17 Additionally, intraepithelial CD8⁺ tumor-infiltrating lymphocytes (TILs) expressing CD103 have been strongly associated with patient survival in high-grade serous ovarian cancer (HGSC).¹⁸

Specifications

1. Morgan EA, et al. Immunohistochemical detection of hairy cell leukemia in paraffin sections using a highly effective CD103 rabbit monoclonal antibody. Am J Clin Pathol. 2013 Feb; 139(2):220-30.
2. Dong HY, et al. Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics. Am J Clin Pathol. 2009 Apr; 131(4):586 -95.
3. Mori N, et al. TIA-1 expression in hairy cell leukemia. Mod Pathol. 2004 Jul; 17 (7):840-6.
4. Webb JR, et al. Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer. Clin Cancer Res. 2014 Jan 15; 20(2):434-44.
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.