CD68 [KP1]

Product Description

The CD68 antigen is a 110 kDa highly glycosylated transmembrane protein which is mainly located in lysosomes. Studies have shown the antibody stains macrophages in many human tissues including Kupffer’s cells and macrophages in the red pulp of the spleen, in lung alveoli, in lamina propria of the gut, and in the bone marrow. ¹⁵ Antigen-presenting cells are either negative or show weak and/or restricted areas of reactivity. Peripheral blood monocytes are also positive with granular staining pattern. The antibody reacts with myeloid precursors and peripheral blood granulocytes.^16-19 In addition, the antibody reacts with plasmacytoid T-cells that are present in many reactive lymph nodes, and are believed to be of monocyte/macrophage origin.19 The antibody marks the malignant cells in chronic and acute myeloid leukemia.¹⁶ A positive staining of normal and neoplastic mast cells is seen with the antibody, as well as staining of a variable number of cells in malignant melanomas.¹⁸ Studies have shown that CD68 (KP1) is formalinsensitive and false negatives can occur without proper pretreatment.

Specifications

1. Horny HP, et al. Hum Pathol. 1993 Apr; 24(4):355-8.
2. Carbone A, et al. Hum Pathol. 1993 Aug; 24(8):886-96.
3. Gottfried E, et al. Scand J Immunol. 2008 May; 67(5):453-63.
4. Kunz-Schughart LA, et al. Verh Dtsch Ges Pathol. 2003; 87:215-23.
5. Horny HP, et al. Hum Pathol. 1994 Aug; 25(8):810-4.