CD1a [O10]

Product Description

CD1a is a protein of 43 to 49 kDa and is expressed on dendritic cells and cortical thymocytes (1,2). CD1a [O10] staining has been shown to be useful in the differentiation of Langerhans cells from interdigitating cells. It has also proved useful for phenotyping Langerhans cell histiocytosis (2,3). CD1a may be a novel biomarker for Barrett’s metaplasia, and its expression may help to predict the prognosis of this pathology (4).

Specifications

1. Krenacs L, et al. Immunohistochemical detection of CD1A antigen in formalin-fixed and paraffin-embedded tissue sections with monoclonal O10. J Pathol. 1993 Oct;171
(2):99-104.
2. Fivenson DP, et al. Distinctive dendritic cell subsets expressing factor XIIIa, CD1a, CD1b and CD1c in mycosis fungoides and psoriasis. J Cutan Pathol. 1995 Jun;22
(3):223-8.
3. Emile JF, et al. Langerhans’ cell histiocytosis. Definitive diagnosis with the use of monoclonal antibody O10 on routinely paraffin-embedded samples. Am J Surg Pathol.
1995 Jun;19(6):636-41.
4. Cappello F, et al. CD1a expression by Barrett’s metaplasia of gastric type may help to predict its evolution towards cancer. Br J Cancer. 2005 Mar 14;92(5):888-90.
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.