CD20 antibody [L26] reacts with a protein of a 30-33 kDa polypeptide present in B-cells. L26 has been shown to react with the majority of B-cells present in peripheral blood and lymphoid tissues. In normal lymphoid tissue, CD20 [L26] marks B-cells in germinal centers, particularly immunoblasts. This antibody has been shown to be a reliable pan B-cell marker. Studies also show CD20 [L26] marking diffuse large B-cell lymphomas. CD20 [L26] rarely marks T-cells.