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This antibody reacts with Herpes Simplex Virus (HSV) 1 and 2. Herpes Simplex Virus 1 and 2 antibody identifies major viral envelope glycoproteins and core proteins that can be found in the cytoplasm and/or nucleus. HSV can infect both the peripheral and central nervous system. Studies have shown that HSV Type 1 infects tissues such as lung and esophagus and HSV Type 2 infects the genitals and anus. This antibody does not cross-react with cytomegalovirus, Epstein-Barr virus, or varicella zoster virus and is compatible with formalin fixation; however, prolonged fixation can be detrimental to HSV staining.
Herpes Simplex Virus
Nuclear and cytoplasm
HSV infected tissues
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1. Martin JR, et al. Type-specific identification of herpes simplex and varicella-zoster virus antigen in autopsy tissues. Hum Pathol. 1991 Jan;22(1):75-80.
2. Tomita T, et al. Identification of herpes simplex virus infection by immunoperoxidase and in situ hybridization methods. Virchows Arch A Pathol Anat
3. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.