The oncogene-encoded protein c-Myc is postulated to play a role in activating the transcription of growth related genes. Amplification of the c-Myc gene has been found in several types of human tumors. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in neoplastic disease. c-Myc oncogene activity may also be necessary for the translocation(s) seen in human breast tumors identified to have a poor-prognosis signature. Over-expression of the c-Myc oncogene has been implicated in the development and progression of human prostate carcinoma.