Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown Tyrosinase antibody to be a more sensitive marker for melanoma when compared to HMB45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB45. Unlike HMB45, Tyrosinase does not discriminate between activated or resting melanocytes. Other studies have shown Tyrosinase to be a very specific marker for melanomas that did not cross react with any tumors or normal tissues tested. Tyrosinase is reported to be a superior melanoma marker when compared to HMB45.