Studies have shown that calcitonin antibody reacts with the human protein calcitonin and labels C-cells in normal thyroid. Calcitonin antibody has been reported to be particularly useful in differentiating medullary carcinoma from papillary and follicular thyroid cancer. Most medullary carcinomas are positive for calcitonin; conversely, most papillary and follicular types of thyroid cancer are usually negative for calcitonin. When used in conjunction with TTF-1 thyroid medullary carcinoma may be distinguishable from laryngeal moderately differentiated carcinoma.
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