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Arginase-1 (ARG-1) is a key enzyme of the urea cycle found in liver that catalyzes the conversion of L-arginine into L-ornithine and urea. ARG-1 is a highly specific and sensitive marker of benign and hepatocellular carcinoma (HCC) which is now a key target for the differential diagnosis of HCC from metastatic tumors to the liver (1-3). ARG-1 is very specific and has been shown to be more sensitive than Hep Par 1 and Glypican 3 in hepatocellular carcinomas (1-2).
Cytoplasmic and nuclear
Normal human liver
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1. Fujiwara M, et al. Arginase-1 is a more sensitive marker of hepatic differentiation than HepPar-1 and Glypican-3 in fine needle aspiration biopsies. Cancer (Cancer Cytopathol) 2012; 120: 230-7.
2. Timek DT, et al. Arginase-1, HepPar-1, and Glypican-3 are the most effective panel of markers in distinguishing hepatocellular carcinoma from metastatic tumor on fineneedle aspiration specimens. Am J Clin Pathol. 2012; 138: 203-210.
3. Yan BC, et al. Arginase-1: A new immunohistochemical marker of hepatocytes and hepatocellular neoplasms. Am J Surg Pathol. 2010; 34(8): 1147-1154.
4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
5. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.