ALK Antibody (p80) recognizes the formalin-resistant epitope of native anaplastic lymphoma kinase (ALK) protein. ALK Antibody specifically labels t(2;5)-positive cells giving strong cytoplasmic staining that is also associated with nuclear staining. Anaplastic large cell lymphoma (ALCL) is a heterogeneous group of diseases by morphology, immunophenotyping and clinical presentation that can be difficult to diagnose because of its similarity to Hodgkin’s lymphoma. Research has shown that ALK stains the majority of CD30+ ALCL. It has been shown to not stain Hodgkin’s disease (Reed-Sternberg cells). ALK may be used in a panel with CD15, CD30, TIA-1 and EMA.