Microphthalmia Transcription Factor antibody (MiTF) is a nuclear melanocytic marker. Studies have shown it is a sensitive and specific marker for malignant melanoma, including some spindle-cell variants. MiTF has been shown to have superior sensitivity and specificity to S100 and HMB45. MiTF may be useful for identification of melanoma, melanocytic soft tissue tumors and the unusual group of tumors that show combined melanocytic and myloid differentiation, the perivascular epithelioid cell family of tumors (PEComas). Microphthalmia Transcription Factor may be a valuable addition to a melanoma marker panel with S-100, HMB45, Tyrosinase and MART-1.