Napsin A
Napsin A is a pepsin-like aspartic proteinase. It is expressed in type II pneumocytes and in adenocarcinomas of the lung and kidney. Studies have shown that Napsin A is both a more sensitive and specific marker than TTF-1 and is extremely specific for lung adenocarcinomas. Most studies show Napsin A is 100% specific for lung adenocarcinoma versus lung SqCC.
When used in combination, the Desmoglein 3 + Napsin A antibody cocktail are very sensitive and specific markers for discriminating between lung squamous cell carcinoma and lung adenocarcinoma. Used as a panel with TTF-1 and CK5, this antibody cocktail is extremely accurate and may be used as a first-line screener for lung cancer.
*Part of the PulmoPanel™ Kit for diagnosing lung cancer, to order use Cat. No. PPM 435 AAK.
The PulmoPanel™ Kit includes: CK5, Desmoglein 3, Napsin A, p63, TRIM29 and TTF-1.
| Specifications | |
|---|---|
| Intended Use | IVD |
| Source | Rabbit Polyclonal |
| Species Reactivity | Human, Others not tested |
| Clone | N/A |
| Isotype | N/A |
| Antigen | Napsin A |
| Cellular Localization | Cytoplasmic (granular) |
| Positive Control | Lung adenocarcinoma |
| Normal Tissue | Lung |
| Abnormal Tissue | Lung adenocarcinoma, Some thyroid cancers |
| Ordering Information | Catalog Number | Volume |
|---|---|---|
| Concentrate | N/A | N/A |
| Predilute | PP 434 | AA |
| intelliPATH™ | N/A | N/A |
| VP Echelon | N/A | N/A |
| A / AK = 0.1 ml | B / BK = 0.5 ml | C / CK = 1.0 ml | G5 = 5.0 ml | AA = 6.0 ml | H / G25 = 25 ml | L = 100 ml |
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| Data Sheets |
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| Download Data Sheet |
