p63 + P504S (PIN)

Clear
Related Products

P504S is an enzyme in the ß-oxidation of branched-chain fatty acids. Expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. p63, a homolog of the tumor suppressor p53, encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives. Expression of p63 is detected in prostate basal epithelial nuclei in normal prostate; however, is negative in malignant tumors of the prostate gland. p63 + P504S antibody may be an extremely useful aid in diagnosing prostatic intraepithelial neoplasia (PIN), especially in difficult and limited tissues cases.

Intended Use

RUO

Species Reactivity

Human

Source

Mouse Monoclonal, Rabbit Polyclonal

Clone

4A4 N/A

Isotype

IgG, IgG2a/kappa

Antigen

p63 P504S

Localization

Nuclear Granular Cytoplasm

Positive Control

Normal prostate and prostate adenocarcinoma

1. Yang A, et. al. p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities. Mol Cell. 1998;2:305-16.
2. Signoretti S, et. al. p63 Is a Prostate Basal Cell Marker and Is Required for Prostate Development. Am J Pathol. 2000;157:1769-75.
3. Ferdinandusse S, et. al. Subcellular localization and physiological role of α- methylacyl-CoA racemase. J Lipid Res. 2000; 41:1890-6.
4. Xu J, et. al. Identification of Differentially Expressed Genes in Human Prostate Cancer Using Subtraction and Microarray. Cancer Res. 2000; 60:1677-82.
5. Rubin MA, et. al. α-Methylacyl Coenzyme A Racemase as a Tissue Biomarker for Prostate Cancer. JAMA. 2002; 287:1662-70.
6. Luo J, et. al. Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer. Cancer Res. 2002; 62:2220-6.
7. Zhou M, et. al. Alpha-Methylacyl-CoA Racemase A Novel Tumor Marker Overexpressed in Several Human Cancers and Their Precursor Lesions. Am J Surg Pathol. 2002; 26:926-31.
8. Wu CL, et. al. Analysis of α-Methylacyl-CoA Racemase (P504S) Expression in High-Grade Prostatic Intraepithelial Neoplasia. Hum Pathol. 2004; 35:1008-13.
9. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
10. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.

Reviews


There are no reviews yet.

Be the first to review “p63 + P504S (PIN)”