Prostate tissue stained with p63 antibody

p63

SKU: 163 Categories: Cervical, Head and Neck, intelliPATH Antibodies, Oncore Antibodies, P, Primary Antibodies, Prostate, VP Antibodies Tags: 163, CM 163, CM163, IP 163, IP163, OAI 163, OAI163, PM 163, PM163, VP 163, VP163

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p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives. p63 is detected in prostatic basal cells in normal prostate; however, it is negative in malignant tumors of the prostate gland. Thus p63 antibody may be a valuable tool in the differential diagnosis of benign and malignant tumors of prostate gland and can be used in a panel of antibodies such as HMW CK [34ßE12], PSA and PSAP. p63 may play a significant role in prostate development by maintaining a prostate stem cell population. Striated muscle staining may be observed with p63.

Intended Use	IVD
Species Reactivity	Human, Mouse, Rat
Source	Mouse Monoclonal
Clone	4A4
Isotype	IgG2a/kappa
Antigen	p63
Localization	Nuclear
Positive Control	Normal prostate

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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

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