This antibody reacts with human Alpha-1-Fetoprotein (AFP). Alpha-1-Fetoprotein antibody reacts with germ-cell tumors, gonadal tumors and liver carcinoma. Neoplasms commonly associated with Alpha-1-Fetoprotein (AFP) production are hepatocellular carcinomas and some germ cell tumors, typically yolk sac tumor. Rare tumors of visceral origin may also be associated with Alpha-1-Fetoprotein (AFP) production. Studies show that in hepatocellular carcinoma, Alpha-1-Fetoprotein (AFP) expression usually indicates malignancy in a hepatocellular nodule and hepatocytic histogenesis of a malignancy. Traces of contaminating antibodies have been removed by solid-phase absorption with human plasma proteins.