Tumor Associated Glycoprotein

Product Description

The Tumor Associated Glycoprotein [B72.3] antibody is a mouse monoclonal antibody developed for the detection of a high molecular weight (>1,000 kDa) oncofetal glycoprotein known as TAG-72. TAG-72 exhibits properties consistent with a mucin-like glycoprotein and is associated with various human adenocarcinomas.¹⁶

TAG-72 expression has been observed in the majority of adenocarcinomas, including those originating in the colorectal, pancreatic, gastric, ovarian, endometrial, mammary, and non-small cell lung tissues. In contrast, weak or no reactivity has been noted in most normal adult tissues, with the exception of secretory endometrium. Additionally, approximately 60% of carcinoma patients exhibit TAG-72 expression in serum.¹⁶

The immunohistochemical (IHC) detection of TAG-72 using the B72.3 antibody may be used as an aid in identifying adenocarcinomas. It has been reported to be useful in distinguishing pulmonary adenocarcinomas, which may stain positively with B72.3, from pleural mesotheliomas, which typically do not express TAG-72.^15-16

Specifications

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Van Niekerk CC, Vooijs P, Casparie-van Velsen IJ, Poels LG. Differentiation margins of ovarian tumor pathology: first incidences of epithelial ovarian tumors monitored by marker antibodies. Cancer Detect Prev 1997;21(3):247-257, 1997.
2. Guadagni F, Roselli M et al. TAG-72 expression and its role in the biological evaluation of human colorectal cancer. Anticancer Res, Jul;16(4B):2141-2148, 1996.
3. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
4. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.