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Studies have shown that Glypican-3 antibody (GPC3) protein is expressed in most hepatocellular carcinomas (HCC), but is undetectable in normal liver and benign hepatic lesions, including dysplastic and cirrhotic nodules. GPC3 is also significantly elevated in the serum of most patients with HCC. Several studies report that Glypican-3 is a sensitive diagnostic marker for HCC and a tool for differentiating HCC from non-neoplastic and pre-neoplastic liver disease. Our TMA-based studies have shown that Glypican-3 is positive in 90.4% (66/73) of hepatocellular carcinoma cases and negative in 100% of cholangiocellular carcinoma, normal liver and hyperplasia cases.
Last 70 amino acids of the core protein
Membrane & Cytoplasm
1. Kandil DH, et al., Glypican-3 A novel diagnostic marker for hepatocellular carcinoma and more. Adv Anat Pathol. 16(2): 125-9., 2009.
2. Shirakawa H, et al., Glypican-3 is a useful diagnostic marker for a component of hepatocellular carcinoma in human liver cancer. Int. J. Oncol., 34(3): 649-56, 2009.
3. Wang XY, et al., Glypican-3 expression in hepatocellular tumors: diagnostic value for preneoplastic lesions and hepatocellular carcinoma. Human Pathol., 37(11): 1435 -41. 2006.
4. Libbrecht L, et al, Glypican-3 expression distinguishes small hepatocellular carcinoma from cirrhosis, dysplastic nodules, and focal nodular hyperplasia-like nodules. Am. J. Surg. Pathol., 30(11): 1405-11. 2006.
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