CD79a antibody is an intracellular component of the signal transduction pathway of the B-cell Receptor, appearing at pre-B-cell stage and persisting until the plasma cell stage. Studies have shown that CD79a is found in a majority of acute leukemia of precursor-B-cell-type as well as B-cell neoplasms, B-cell lymphomas and some myelomas. It is not present in myeloid or T-cell lines. This antibody labels precursor B-cell acute lymphoblastic leukemia, and has been suggested as the most reliable B-cell marker for this disorder. CD79a is conserved across species, which may make it useful in the identification of B-cell lymphomas in species other than human.
1. Milner RJ, et al. Onderstepoort J Vet Res. 1996 Dec; 63(4):309-313.
2. Astsaturov IA, et al. Leukemia. 1996 May; 10(5):769-73.
3. Chetty R, et al. J Clin Pathol. 1995 Nov; 48(11):1035-8.
4. Hemsley SW, et al. Immunol Cell Biol. 1995 Aug; 73(4):321-5.
5. Mason DY, et al. Blood. 1995 Aug; 86(4):1453-9.