Human CD10 antibody, also known as common acute lymphoblastic leukemia (CALLA), has been shown to react with TdT+ lymphoblastic leukemia, follicular germinal cell lymphoma, Burkitt’s lymphoma and chronic myelocytic leukemia. CD10 also marks normal early lymphoid progenitor cells, immature B-cells in adult bone marrow and germinal cells in normal tonsil and normal lymphoid tissue. It is also expressed in some non-lymphoid tissues such as fibroblasts, breast myoepithelium and brush border of kidney. CD10 antibody may be used in a panel for mantle cell lymphoma with Cyclin D1 (+), CD43 (+), CD5 (+), IgM (+), CD23 (-) and CD10 (-).
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