CD3 antibody (P) reacts with the intracytoplasmic portion of the CD3 antigen expressed by T cells. Studies have shown that CD3 stains human T-cells in both the cortex and medulla of the thymus and in peripheral lymphoid tissues. CD3 is regarded as a reliable pan T-cell antibody used in the immunophenotyping of T-cell lymphomas in paraffin sections with the majority of T-cell lymphomas expressing positivity for CD3. Studies have shown that when used in conjunction with LCA and CD20 [L26], CD3 (P) can determine cell lineage in the majority of non-Hodgkin’s lymphoma.
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