Smooth Muscle Actin

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This antibody recognizes the alpha-smooth muscle isoform of actin. It shows no crossreaction with actin from fibroblasts (beta- and gamma-cytoplasmic), striated muscle (alpha-sarcomeric), and myocardium (alpha-myocardial). Its epitope is composed of the acetyl group and the first 4 amino acids on the N-terminal end of the peptidic chain of alpha-smooth actin. BIOCARE’s 1A4 MAb stains smooth muscle cells in vessel walls, gut wall, and myometrium. Myoepithelial cells in breast and salivary glands are also stained as they also contain actin. This MAb is reportedly useful for identifying tumors arising from smooth muscle and myoepithelial cells.

Intended Use

IVD

Species Reactivity

Cat, Dog, Horse, Human, Mouse, Rat, Sheep

Source

Mouse Monoclonal

Clone

1A4 (also known as asm-1)

Isotype

IgG2a /kappa

Antigen

Smooth Muscle Actin

Localization

Cytoplasmic

Positive Control

Blood vessels, leiomyoma or leiomyosarcoma

1. Sheehan M, O’Briain DS. False-positive immunoractivity with muscle-specific actins in non-Hodgkin’s lymphomas. Arch Pathol Lab Med, 1995, Mar;119(3):225-228.
2. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
3. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.

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