Muscle Specific Actin

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The Muscle Specific Actin antibody [HHF35] recognizes muscle specific alpha and gamma actin isomers. It does not react with non-muscle actin. Studies have shown that it recognizes the alpha actin from cardiac, skeletal and smooth muscle sources. It does not react with beta or non-smooth muscle gamma actin isomers. The antibody labels leiomyoma, leiomyosarcoma, angiomyolipoma and rhabdomyosarcoma. It does not label melanoma or lymphoma. A study has suggested [HHF35] aids the differential diagnosis of Collagenous Spherulosis and Adenoid-Cystic Carcinoma of the breast.

Intended Use


Species Reactivity



Mouse Monoclonal




IgG1 /kappa





Positive Control

Leiomyoma, leiomyosarcoma, muscle or prostate

1. Rangdaeng S and Truong LD. Comparative immunohistochemical staining for desmin and muscle-specific actin. A study of 576 cases. Am J Clin Pathol 1991 Jul; 96 (1):32-45.
2. Miettinen M. Antibody specific to muscle actins in the diagnosis and classification of soft tissue tumors. Am J Pathol 1988 Jan; 130 (1):205-215.
3. Tsukada T, McNutt MA, Ross R, Gown AM. HHF35, a muscle actin-specific monoclonal antibody. II. Reactivity in normal, reactive, and neoplastic human tissues. J Pathol 1987 May; 127 (2):389-402
4. Norton AJ, Thomas JA, Isaacson PG. Cytokeratin-specific monoclonal antibodies are reactive with tumours of smooth muscle derivation. An immunocytochemical and biochemical study using antibodies to intermediate filament cytoskeletal proteins. Histopathology 1987 May; 11 (5):487-499
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.


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