Napsin A

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Napsin A is a pepsin-like aspartic proteinase. It is expressed in type II pneumocytes and in adenocarcinomas of the lung and kidney. Studies have shown that Napsin A is both a more sensitive and specific marker than TTF-1 and is extremely specific for lung adenocarcinomas. Most studies show Napsin A is 100% specific for lung adenocarcinoma versus lung SqCC.
When used in combination, Desmoglein 3 + Napsin A are very sensitive and specific markers for discriminating between lung squamous cell carcinoma and lung adenocarcinoma. Used as a panel with TTF-1 and CK5, this antibody combination is extremely accurate and may be used as a first-line screener for lung cancer.

Intended Use

IVD

Species Reactivity

Human, Others Not Tested

Source

Rabbit Polyclonal

Clone

N/A

Isotype

N/A

Antigen

Human Napsin A

Localization

Cytoplasmic (granular)

Positive Control

Lung adenocarcinoma

1. Mukhopadhyay S, Katzenstein AL. Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am J Surg Pathol. 2011 Jan; 35(1):15-25.
2. Bishop JA, Sharma R, Illei PB. Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma. Hum Pathol. 2010 Jan; 41(1):20-5. Epub 2009 Sep 8.
3. Jagirdar J. Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung. Arch Pathol Lab Med. 2008 Mar; 132(3):384-96.
4. Dejmek A, et al. Napsin A (TA02) is a useful alternative to thyroid transcription factor-1 (TTF-1) for the identification of pulmonary adenocarcinoma cells in pleural effusions. Diagn Cytopathol. 2007 Aug; 35(8):493-7.
5. Suzuki A, et al. Napsin A is useful to distinguish primary lung adenocarcinoma from adenocarcinomas of other organs. Pathol Res Pract. 2005; 201(8-9):579-86.
6. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
7. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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