MUM-1

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Multiple myeloma oncogene-1 (MUM-1) is a lymphocyte-specific member of the interferon regulatory factor family of transcription factors encoded by the MUM-1 gene. MUM-1 antibody is expressed in the nuclei and cytoplasm of plasma cells and a small fraction of B-cells located in the light zone of germinal centers. MUM-1 labels centrocytes and their progeny, plasma cells, activated T-cells and a wide spectrum of hematolymphoid neoplasms derived from these cells. MUM-1 has been reported to play an important role in mediating B-cell activation and differentiation. Therefore, this antibody may be used as a tool for the identification and the sub classification of lymphoid malignancies.

Intended Use

IVD

Species Reactivity

Human

Source

Rabbit Monoclonal

Clone

BC5, Biocare Clone

Isotype

IgG

Antigen

MUM-1 protein

Localization

Nuclear, cytoplasmic

Positive Control

Tonsil

1. Carbone A, Gloghini A, Aldinucci D, Gattei V, Dalla-Favera R, Gaidano G. Expression pattern of MUM1/IRF4 in the spectrum of pathology of Hodgkin’s disease. Br J Haematol. 2002 May;117(2):366-72.
2. Falini B, Mason DY. Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry. Blood. 2002 Jan 15;99(2):409-26.
3. Johnson LR, Nalesnik MA, Swerdlow SH. Impact of Epstein-Barr virus in monomorphic B-cell posttransplant lymphoproliferative disorders: a histogenetic study. Am J Surg Pathol. 2006 Dec;30(12):1604-12.
4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
5. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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