Inhibin, Alpha

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Inhibin, Alpha antibody [BC/R1] recognizes the 32 kDa alpha subunit of human inhibin. Inhibin is a peptide hormone that is produced by ovarian granulosa cells which inhibits the release of Follicle-Stimulating Hormone (FSH). The Inhibin alpha antibody subunit is expressed in a wide range of human tissues outside the reproductive axis such as prostate, brain, adrenal, as well as in the granulosa cells of the ovary, Sertoli cells of the testis and various cells of the fetoplacental unit. Inhibin may be used as a differential marker for adrenocortical tumors, placenta and gestational trophoblastic lesions and sex cord stromal tumors.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

BC/R1

Isotype

IgG2a

Antigen

Inhibin alpha subunit

Localization

Cytoplasmic

Positive Control

Normal testis or normal ovary, adrenal gland

1. Groome, N G et al (1990) Monoclonal and polyclonal antibodies reactive with the 1-32 amino terminal sequence of the alpha subunit of human 32K inhibin. Hybridoma 9 (1): 31-42
2. Groome, N G et al (1991) Preparation of monoclonal antibodies to beta A subunit of ovarian inhibin using a synthetic peptide immunogen. Hybridoma 10(2): 309-316
3. Arora, D S et al (1997) Immunohistochemical expression of inhibin/activin subunits in epithelial and granulosa cell tumours of the ovary. Journal of Pathology 181: 413-418
4. McCluggage WG. Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms. J Clin Pathol 2000 May;53(5):327-34
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. National Committee for Clinical Laboratory Standards(NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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