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Mouse anti-human folate receptor alpha antibody monoclonal [26B3.F2] specifically recognizes the alpha isoform of folate receptor. Folate receptor alpha is primarily expressed in the apical surface of some polarized epithelial cells of normal tissues (such as kidney, lung, breast, and salivary glands) and on many cancer cells of epithelial origin; namely, ovarian cancer, thyroid cancer, non-small cell lung adenocarcinoma (NSCLC) and endometrial cancer.
In the most widely studied tumor, epithelial ovarian cancer, expression of FRalpha increases with tumor stage , and is associated with decreased survival . However, in NSCLC, FRalpha has been shown to be specific for adenocarcinomas relative to squamous cell carcinoma and other histologic subtypes, and increased expression has been correlated to increased survival [4,9].
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2. O’Shannessy DJ, et al. Characterization of the human folate receptor alpha via novel antibody-based probes. Oncotarget. 2011 Dec;2(12):1227-43.
3. Basal E, et al. Functional folate receptor alpha is elevated in the blood of ovarian cancer patients. PLoS One. 2009 Jul; 4(7):e6292.
4. Xia W, et al. A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Blood. 2009 Jan; 113(2):438-46.
5. Iwakiri S, et al. Expression Status of Folate Receptor a Is Significantly Correlated with Prognosis in Non-Small-Cell Lung Cancers. Ann Surg Oncol. 2008; 15(3):889–99.
6. Smith AE, et al. A Novel Monoclonal Antibody for Detection of Folate Receptor Alpha in Paraffin-Embedded Tissues. Hybridoma. 2007; 26(5):281-8.
7. Parker N, et al. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem. 2005 Mar; 338(2):284-93.
8. Elnakat H, Ratnam M. Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. Adv Drug Deliv Rev. 2004 Apr; 56(8):1067-84.
9. Matherly LH, Goldman DI. Membrane transport of folates. Vitam Horm. 2003; 66:403-56.
10. Garber ME, et al. Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci USA. 2001 Nov; 98(24): 13784-9.
11. Choi SW, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr. 2000; 130(2):129–32.
12. Toffoli G, et al. Expression of folate binding protein as a prognostic factor for response to platinum-containing chemotherapy and survival in human ovarian cancer. Int J Cancer. 1998 Apr; 79(2):121–6.
13. Toffoli G, et al. Overexpression of folate binding protein in ovarian cancers. Int J Cancer. 1997 Apr; 74(2):193-8.
14. Garin-Chesa P, et al. Trophoblast and Ovarian Cancer Antigen LK26. Sensitivity and Specificity in Immunopathology and Molecular Identification as a Folate-Binding Protein. Am J Pathol. 1993 Feb; 142(2):557-67.
15. O’Shannessy DJ, et al. Gene expression analyses support fallopian tube epithelium as the cell of origin of epithelial ovarian cancer. Int J Mol Sci. 2013 Jul; 14(7):13687-703.
16. Bremer RE, et al. Interobserver Agreement and Assay Reproducibility of Folate Receptor α Expression in Lung Adenocarcinoma: A Prognostic Marker and Potential Therapeutic Target. Arch Pathol Lab Med. 2013 Apr 9. [Epub ahead of print] 17. Despierre E, et al. Folate receptor alpha (FRA) expression remains unchanged in epithelial ovarian and endometrial cancer after chemotherapy. Gynecol Oncol. 2013 Jul;130(1):192-9.
18. O’Shannessy DJ, et al. Expression of folate receptor-α (FRA) in gynecologic malignancies and its relationship to the tumor type. Int J Gynecol Pathol. 2013 May; 32(3):258-68.
19. Christoph DC, et al. Significance of folate receptor alpha and thymidylate synthase protein expression in patients with non-small-cell lung cancer treated with pemetrexed. J Thorac Oncol. 2013 Jan; 8(1):19-30.
20. O’Shannessy DJ, et al. Folate receptor alpha (FRA) expression in breast cancer: identification of a new molecular subtype and association with triple negative disease. SpringerPlus. 2012; 1:22.
21. Tacha D, Bremer R. Folate Receptor alpha is Frequently Expressed in Triple Negative Breast Cancers. Mod Path. 2013 Feb;26(Supplement 2s):71A.
22. College of American Pathologists (CAP) Certification Program for Immunohistochemistry. Northfield IL. http://www.cap.org (800) 323-4040.
23. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
24. O’Leary TJ, et al. Quality assurance for immunocytochemistry; Proposed guideline. MM4-P. National Committee for Clinical Laboratory Standards (NCCLS). Wayne, PA. 1997; 1-46.
25. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.