Ki-67 (R)

SKU: 325, ki67 Categories: , , , ,
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Ki-67 rabbit antibody is a non-histone protein expressed in the nucleus during the whole cell cycle, except in the G0 and G1 early phases. Therefore, Ki-67 constitutes an efficient marker of proliferating cells. Due to its role in the cell cycle, the fraction of Ki-67 positive cells in a given tissue sample has often been cited as a useful index for grading the proliferation rates of tumors; including lesions of the breast, brain, cervix and prostate. In pre-cancerous lesions, the Ki-67 labeling index has been associated with an increasing degree of cervical dysplasia. Ki-67 has also been reported as a useful prognostic marker for breast cancer.

Intended Use


Species Reactivity

Cat, Cow, Dog, Human, Mouse, Pig, Rat, Sheep


Rabbit Monoclonal









Positive Control

Tonsil or breast cancer

1. Jansen R, et al. MIB-1 labelling index is an independent prognostic marker in primary breast cancer. Br J Cancer 1998 Aug; 78 (4):460-465.
2. Goodson WH, et al. The functional relationship between in vivo bromodeoxyuridine labeling index and Ki-67 proliferation index in human breast cancer. Breast Cancer Res Treat 1998 May; 49 (2): 155-164.
3. Rossi S, et al. A comparative study between a novel category of immunoreagents and the corresponding mouse monoclonal antibodies. Am J Clin Pathol 2005; 124(2): 295-302.
4. Pena LL, et al. Immunohistochemical detection of Ki-67 and PCNA in canine mammary tumors: relationship to clinical and pathologic variables. J Vet Diag Invest 1998 Jul; 10 (3):237-246.
5. Gibbons D, et al. Comparison of topoisomerase II alpha and MIB-1 expression in uterinecervical squamous lesions. Mod Pathol 1997 May; 10 (5): 409-413.
6. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
7. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005


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