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This Epithelial Membrane Antigen antibody has been shown to be reactive against many types of adenocarcinoma. Breast and skin adnexal tumors are strongly positive. Various studies have demonstrated a lesser degree of EMA staining in endometrial, kidney, thyroid, stomach, pancreas, lung, and colon, ovarian, prostate and cervical carcinomas. Studies have shown that embryonal carcinomas, medullary carcinomas of thyroid, squamous carcinomas, sarcomas, lymphomas, and melanomas all tend to be nonreactive or show rare positive cells. Transitional cell carcinomas may show weak reactivity. Note that the cells of anaplastic large cell lymphoma are positive for EMA in a minority of cases. .
Cytoplasm, cell membrane
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