CDX2 + CK7

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Studies show CDX2 is a sensitive marker for colonic carcinoma metastatic to the ovary and is more specific than CK20 as it is not expressed by serous and endometrioid carcinomas. CDX2 is also expressed in mucinous ovarian carcinomas. CDX2 is reported to be advantageous over CK20 for distinguishing primary ovarian tumors from metastases of upper gastrointestinal tract origin. Cytokeratin 7 shows expression in primary ovarian tumors and metastases of upper gastrointestinal tract origin. A CDX2 and CK7 panel may help in distinguishing colonic carcinomas metastatic to the ovaries from primary ovarian carcinomas.

Intended Use


Species Reactivity



Mouse Monoclonal, Rabbit Monoclonal


CDX2-88 + BC1


IgG1 and IgG


CDX2 and CK7


CDX2: (nuclear); brown CK7: (cytoplasmic); red

Positive Control

Colon, breast, ovary and lung cancers

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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Kim MJ. J Korean Med Sci. 2005 Aug; 20(4):643-8.
2. Vang R, et al. Mod Pathol. 2006 Nov; 19(11):1421-8.
3. Werling RW, et al. Am J Surg Pathol. 2003 Mar; 27(3):303-10.
4. Raspollini MR, et al. Appl Immunohistochem Mol Morphol. 2004 Jun; 12(2):127-31.
5. Groisman GM, Meir A, Sabo E. Int J Gynecol Pathol. 2004 Jan; 23(1):52-7.


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