CD45RO [UCHL-1]

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CD45RO antibody recognizes an 180 kDa protein, identified as isoform of leukocyte common antigen (CD45RO). Studies have shown the CD45RO antibody reacts with mature activated T-cells, most thymocytes and a sub-population of resting T-cells within both CD4 and CD8 subsets. Reportedly, the UCHL-1 clone of the CD45RO antibody is useful for the identification of normal T-cells and T-cell lymphomas. Other studies have demonstrated that UCHL-1 shows no reactivity with normal B-cells or natural killer cells, but reacts with granulocytes and monocytes.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

UCHL-1

Isotype

IgG2a/kappa

Antigen

CD45RO

Localization

Cell Membrane

Positive Control

Tonsil or T-cell lymphoma

1. Zlobec I, et al. J Transl Med. 2013 Apr; 11(1):104. [Epub ahead of print] 2. Fraga M, et al. Histopathology. 2002 Sep; 41(3):216-29.
3. Kurtin PJ, Roche PC. Am J Surg Pathol, 1993 Sep; 17(9):898-904.
4. Clark JR, Williams ME, Swerdlow SH. Am J Clin Pathol. 1990 Jan; 93(1):58-69.

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