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CD3 antibody (P) reacts with the intracytoplasmic portion of the CD3 antigen expressed by T cells. Studies have shown that CD3 stains human T-cells in both the cortex and medulla of the thymus and in peripheral lymphoid tissues. CD3 is regarded as a reliable pan T-cell antibody used in the immunophenotyping of T-cell lymphomas in paraffin sections with the majority of T-cell lymphomas expressing positivity for CD3. Studies have shown that when used in conjunction with LCA and CD20 [L26], CD3 (P) can determine cell lineage in the majority of non-Hodgkin’s lymphoma.
Human, Mouse, Rat
Predominantly cell membrane, some cytoplasmic
Tonsil or T-cell lymphoma
1. Mason DY, et al. J Clin Pathol. 1989 Nov; 42(11):1194-200.
2. Anderson C, et al. Mod Pathol. 1991 May; 4(3):358-62.
3. Cabecadas JM, Isaacson PG. Histopathology. 1991 Nov; 19(5):419-24.