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Terminal Deoxynucleotidyl Transferase antibody (TdT) is a nuclear protein widely used as a marker for lymphoblastic leukemia. TdT is a template-independent DNA polymerase which has been shown to be responsible for the addition of nucleotides at the N-region junction of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. Studies have shown that a panel of antibodies consisting of TdT, CD10, CD99 (MIC2), Bcl-2 and CD34 can be used to distinguish lymphoblastic leukemias from small noncleaved cell lymphomas.
Terminal Deoxynucleotidyl Transferase (TdT)
Lymphoblastic leukemia or fetal thymus
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