Tumor Associated Glycoprotein

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Tumor Associated Glycoprotein antibody [B72.3], also known as TAG-72, has the properties of a mucin. The majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary and non-small cell lung cancer display some cell populations that are positive for TAG-72 staining. Weak or no reactivity has been observed with most cell types of normal adult tissue with the exception of the secretory endometrium. Tumor Associated Glycoprotein [B72.3] is reportedly useful in distinguishing pulmonary adenocarcinomas from pleural mesotheliomas.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

B72.3

Isotype

IgG1 /kappa

Antigen

TAG-72 or B72.3

Localization

Cell Surface and cytoplasmic

Positive Control

Colon carcinoma or breast cancer

Download Data Sheet
Download RUO Data Sheet for International
Download SDS Sheet

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Van Niekerk CC, Vooijs P, Casparie-van Velsen IJ, Poels LG. Differentiation margins of ovarian tumor pathology: first incidences of epithelial ovarian tumors monitored by marker antibodies. Cancer Detect Prev 1997;21(3):247-257, 1997.
2. Guadagni F, Roselli M et al. TAG-72 expression and its role in the biological evaluation of human colorectal cancer. Anticancer Res, Jul;16(4B):2141-2148, 1996.
3. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
4. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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