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Tumor Associated Glycoprotein antibody [B72.3], also known as TAG-72, has the properties of a mucin. The majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary and non-small cell lung cancer display some cell populations that are positive for TAG-72 staining. Weak or no reactivity has been observed with most cell types of normal adult tissue with the exception of the secretory endometrium. Tumor Associated Glycoprotein [B72.3] is reportedly useful in distinguishing pulmonary adenocarcinomas from pleural mesotheliomas.
TAG-72 or B72.3
Cell Surface and cytoplasmic
Colon carcinoma or breast cancer
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2. Guadagni F, Roselli M et al. TAG-72 expression and its role in the biological evaluation of human colorectal cancer. Anticancer Res, Jul;16(4B):2141-2148, 1996.
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