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Mucins are high molecular weight glycoproteins with 80% carbohydrate content and the remaining 20% consisting of a protein core. Mucin 5AC antibody (MUC5AC) is defined as a secretory-type mucin and is seen mainly in gastric foveolar cells. A study has suggested that MUC5AC expression is an early event in tumorigenesis. Another study indicates up-regulation of MUC5AC may be associated with carcinogenesis, malignant potential, progression and clinical behaviors in colorectal signet-ring cell carcinoma.
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