Microphthalmia Transcription Factor (MiTF)
Microphthalmia transcription factor (MiTF) was recently cloned as the human homolog of the mouse microphthalmia (mi) gene product. The mi phenotype is associated with a mutant mi locus and characterized by small eyes and loss of melanin pigments. MiTF is the only nuclear melanocytic marker and is a sensitive and specific marker for malignant melanoma, including some spindle-cell variants, in cytologic specimens, and may be superior to the current standard melanocytic markers, S100 protein and HMB45 antigen. MiTF may be very valuable for the diagnosis of melanoma, including desmoplastic variants; melanocytic soft tissue tumors, such as clear cell sarcoma; and the unusual group of tumors that show combined melanocytic and myoid differentiation, the perivascular epithelioid cell family of tumors (PEComas). Microphthalmia transcription factor may be a valuable addition to the marker panel used in diagnosing melanoma, in combination with S100, HMB45, Tyrosinase and MART-1.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 423 |
BK |
| Predilute |
PM 423 |
AA |
| intelliPATH™ |
N/A |
N/A |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
