VEGF

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Vascular Endothelial Growth Factor (VEGF antibody) is a sub-family of growth factors, more specifically the platelet-derived growth factor family of cystine-knot growth factors. VEGF proteins are important signaling factors involved in both vasculogenesis (the formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). Studies indicate that in certain cancers, high VEGF expression is correlated with shorter survival. This indicates that VEGF antibody is a valuable prognostic marker and holds the potential to be a predictive marker for anti-angiogenic cancer treatment.

Intended Use

RUO

Species Reactivity

Human

Source

Rabbit Monoclonal

Clone

EP1176Y

Isotype

IgG

Antigen

VEGF

Localization

Membrane and / or cytoplasmic

Positive Control

Tonsil, some breast and ovarian cancers

Download OUS Datasheet

Legal Notice

IVD is NOT for Sale in the United States but may be available in certain countries outside of the United States, please contact your local distributor for more information.

1. Saad RS, et al. Lymphatic microvessel density as prognostic marker in colorectal cancer. Modern Pathol. 2006 Oct; 19(10):1317-23.
2. Lee AH, et al. Invasive lobular and invasive ductal carcinoma of the breast show distinct patterns of vascular endothelial growth factor expression and angiogenesis. J Pathol. 1998 Aug; 185(4):394-401.
3. Applanat MP, et al. Vascular endothelial growth factor is a target gene for estrogen receptor and contributes to breast cancer progression. Adv Exp Med Biol. 2008; 617:437-44.
4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
5. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.

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