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SOX11 antibody (SRY (Sex Determining Region Y)-Box 11) is a member of the SOX family of transcription factors and is involved in the regulation of embryonic development and in the determination of cell fate (1). The diagnosis of mantle cell lymphoma (MCL) can be difficult, especially when t(11;14) translocation and cyclin D1 overexpression are not detected. In such cases, the transcription factor SOX11 represents an important diagnostic marker as it is expressed in most MCLs and, in particular, in all cyclin D1- negative MCLs reported so far (2,3). The novel mouse monoclonal SOX11-C1 antibody displays nuclear staining and offers high sensitivity and improved specificity compared to previous SOX11 antibodies in IHC based detection of MCL. In addition, flow cytometry analysis of blood and tissue samples using SOX11-C1 may allow a convenient approach to early diagnosis and follow-up of MCL patients (4). SOX11 expression has also been shown to be a favorable prognostic marker in glioblastoma (5).
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Mantle cell lymphoma
1. Pusch C, et al. The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor. Hum Genet. 1998 Aug; 103(2):115-23.
2. Soldini D, et al. Assessment of SOX11 expression in routine lymphoma tissue sections: characterization of new monoclonal antibodies for diagnosis of mantle cell lymphoma. Am J Surg Pathol. 2014 Jan; 38(1):86-93.
3. Chen YH, et al. Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms. Mod Pathol. 2010 Jan; 23(1):105-12.
4. Nordström L, et al. Expanded clinical and experimental use of SOX11 – using a monoclonal antibody. BMC Cancer. 2012 Jun 27;12:269.
5. Korkolopoulou P, et al. Sox11 expression in astrocytic gliomas: correlation with nestin/c-Met/IDH1-R132H expression phenotypes, p-Stat-3 and survival. Br J Cancer. 2013 May 28;108(10):2142-52.
6. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
7. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.