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Placental S100 (S100P antibody) is a member of S100 protein family, whose members function as extracellular and intracellular regulators of diverse cellular processes. S100P expression has been detected in human tumor cell lines derived from breast, prostate, pancreas, lung and colon; and is associated with a malignant phenotype, hormone independence and chemotherapy resistance. Over-expression of S100P promoted tumorigenesis and metastasis in diverse cancer models. Recent studies have shown that S100P is highly expressed in both the cytoplasm and nucleus of cells in poorly differentiated bladder cancers.
Nuclear and cytoplasmic
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