S100P

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Placental S100 (S100P antibody) is a member of S100 protein family, whose members function as extracellular and intracellular regulators of diverse cellular processes. S100P expression has been detected in human tumor cell lines derived from breast, prostate, pancreas, lung and colon; and is associated with a malignant phenotype, hormone independence and chemotherapy resistance. Over-expression of S100P promoted tumorigenesis and metastasis in diverse cancer models. Recent studies have shown that S100P is highly expressed in both the cytoplasm and nucleus of cells in poorly differentiated bladder cancers.

Intended Use

IVD

Species Reactivity

Dog, Human

Source

Rabbit Polyclonal

Clone

N/A

Isotype

N/A

Antigen

Placental S100

Localization

Nuclear and cytoplasmic

Positive Control

Bladder cancer

1. Esheba GE, et al. Expression of the urothelial differentiation markers GATA3 and placental S100 (S100P) in female genital tract transitional cell proliferations. Am J Surg Pathol. 2009 Mar; 33(3):347-53.
2. Chuang AY, et al. Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma. Am J Surg Pathol. 2007 Aug; 31(8):1246-55.
3. Higgins JP, et al. Placental S100 (S100P) and GATA-3: markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray. Am J Surg Pathol. 2007 May; 31(5):673-80.
4. Gibadulinova A, et al. Transcriptional regulation and functional implication of S100P in cancer. Amino Acids. 2011 Oct; 41(4):885-92.
5. Deng H, et al. Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens. Am J Clin Pathol. 2008 Jan; 129(1):81-8.
6. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
7. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.

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