PAX8

Product Description

PAX8 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. This family plays critical roles during fetal development and cancer growth. PAX8 is involved in kidney cell differentiation, thyroid development, or thyroid dysgenesis. PAX8 has been shown to be expressed in three of the most common types of renal cell carcinoma including clear cell, chromophobe and papillary carcinoma but negative for uroepithelial carcinoma of renal pelvis.^15-17

Specifications

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2. Viktorová T, Babjuk M, Dusková J, Stolz J, Goetz P, Mares J. Expression of PAX2 and PAX8 genes in conventional type of renal carcinoma and their role in the tumor prognosis. Diagn Cytopathol. 2008 Aug; 36(8):568-73.
3. Narlis M, Grote D, Gaitan Y, Boualia SK, Bouchard M. Pax2 and Pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. J Am Soc Nephrol. 2007 Apr; 18(4):1121-9. Epub 2007 Feb 21.
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5. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.