PAX8

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PAX8 Rabbit Antibody is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. This family plays critical roles during fetal development and cancer growth. PAX8 is involved in kidney cell differentiation, thyroid development, or thyroid dysgenesis. Studies show that expression of the PAX8 gene was found in 89% of analyzed tumor samples. The expression of the PAX8 target genes were found in all normal renal samples. PAX8 has been shown to be expressed in three of the most common types of renal cell carcinoma including clear cell, chromophobe and papillary carcinoma but negative for uroepithelial carcinoma of renal pelvis. PAX8 stains nuclei exclusively and performs well in formalin-fixed paraffinembedded tissues. PAX8 has been shown to be a superior marker compared to the Renal Cell Carcinoma Marker (RCC).

Intended Use

IVD

Species Reactivity

Human, Mouse

Source

Rabbit Polyclonal

Clone

N/A

Isotype

N/A

Antigen

PAX8

Localization

Nuclear

Positive Control

Renal tissue

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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Lotan TL, Ye H, Melamed J, Wu XR, Shih IM, Epstein JI. Immunohistochemical Panel to Identify the Primary Site of Invasive Micropapillary Carcinoma. Am J Surg Pathol. 2009 Feb 20.
2. Viktorová T, Babjuk M, Dusková J, Stolz J, Goetz P, Mares J. Expression of PAX2 and PAX8 genes in conventional type of renal carcinoma and their role in the tumor prognosis. Diagn Cytopathol. 2008 Aug; 36(8):568-73.
3. Narlis M, Grote D, Gaitan Y, Boualia SK, Bouchard M. Pax2 and Pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. J Am Soc Nephrol. 2007 Apr; 18(4):1121-9. Epub 2007 Feb 21.
4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
5. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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