Ki-67 + Caspase-3

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SKU: 240ds, ki67, ki-67 Categories: , ,

Ki-67 + Caspase-3 can provide information on cell death vs. cell proliferation in the same tissue section. The Ki-67 nuclear antigen is associated with cell proliferation and is used to grade proliferation rates of tumors. Ki-67 is found throughout the cell cycle that includes the G1, S, G2, and M phases; but not the G0 phase. Apoptosis has gained central importance in the study of many biological processes, including neoplasia, neurodegenerative diseases, and development. Cleaved caspase-3 detects endogenous levels of the large fragment of activated caspase-3, a protease that mediates apoptosis. Caspase-3 does not cross react with other cleaved caspases.

Intended Use

RUO

Species Reactivity

Human

Source

Mouse Monoclonal, Rabbit Polyclonal

Clone

DVB-2

Isotype

IgG1 (Ki-67 only)

Antigen

Ki-67 and Caspase-3

Localization

Ki-67: (nuclear): brown Caspase-3: (cytoplasmic / nuclear): red

Positive Control

Tonsil or Colon Cancer

Download DS Data Sheet
Download RUO Data Sheet for International
Download SDS Sheet

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

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5. Wang L, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Mar; 33(3):222-6.
6. Chrysomali E, et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Nov; 96(5):566-72.

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