Estrogen Receptor (ER) [6F11 + SP1]

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Estrogen Receptor ER antibody clone 6F11 is a 66-kDa protein that mediates the actions of estrogens in estrogen-responsive tissues. The ER gene consists of more than 140kb of genomic DNA divided into 8 exons. These translate into a protein with six functionally discrete domains, labeled A through F. This mouse monoclonal antibody has been established to work in formalin-fixed, paraffin-embedded tissues and has been published in breast cancer studies. The 6F11 clone has been shown to be superior to the 1D5 (Bevitt DJ et al.).

Intended Use

ASR

Species Reactivity

Human

Source

Mouse Monoclonal, Rabbit Monoclonal

Clone

6F11 + SP1

Isotype

IgG1/kappa (6F11) and IgG (SP1)

Antigen

Estrogen Receptor

Localization

Nuclear

Positive Control

Breast Carcinoma

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1. Cheang MC et al. (2006) Immunohistochemical Detection Using the New Rabbit Monoclonal Antibody SP1 of Estrogen Receptor in Breast Cancer Is Superior to Mouse Monoclonal Antibody 1D5 in Predicting Survival. J Clin Oncol. [Epub ahead of print].
2. Kaplan PA et al. (2005) An immunohistochemical comparison of two monoclonal antibodies for the evaluation of estrogen receptor status in primary breast carcinoma. Am J Clin Pathol.123(2):276-80
3. Bevitt DJ et al. (1977) New monoclonal antibodies to oestrogen and progesterone receptors effective for paraffin section immunohistochemistry. J Pathol Oct; 183 (2):228-32.
4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
5. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991; 7(9). Order code M29-P.

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