Human estrogen receptor (ER antibody) is a 66 kDa protein that acts as an estrogen-dependent, nuclear hormone receptor. Studies have shown ER is present in the nuclei of epithelial cells in normal breast and endometrial tissues, as well as a subset of breast carcinomas. The SP1 clone is a high affinity rabbit monoclonal antibody directed against an epitope of the C-terminus of the ER protein. Studies have shown that the SP1 clone has higher sensitivity than available mouse monoclonals in breast cancer. In some instances, SP1 staining can be obtained even without antigen retrieval.
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1. Cheang MC, et al. Immunohistochemical Detection Using the New Rabbit Monoclonal Antibody SP1 of Estrogen Receptor in Breast Cancer Is Superior to Mouse Monoclonal Antibody 1D5 in Predicting Survival. J Clin Oncol. 2006 Dec;24(36):5637 -44.
2. Rossi S, et al. Rabbit monoclonal antibodies: a comparative study between a novel category of immunoreagents and the corresponding mouse monoclonal antibodies. Am J Clin Pathol. 2005 Aug;124(2):295-302.
3. Cano G, et al. Estimation of hormone receptor status in fine-needle aspirates and paraffin-embedded sections from breast cancer using the novel rabbit monoclonal antibodies SP1 and SP2. Diagn Cytopathol. 2003 Oct; 29(4):207-11.
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