CD4 [4B12]

SKU: 3148 Categories: ,

CD4 is a transmembrane glycoprotein, expressed on normal thymocytes, T-helper cells, the majority of mature peripheral T cells, and a subset of suppressor or cytotoxic T cells (1). Like many cell surface receptors/markers, CD4 is a member of the immunoglobulin superfamily. CD4 is expressed in the majority of T-cell lymphomas, including mycosis fungoides (2). CD4 has been used in lymphoma panels that include CD3, CD5, CD8, CD7 and TIA-1 (2-3). A panel consisting of CD4(+), CD2(-) and CD56(+) antibodies was also used to help identify agranular natural killer cell lymphoma of the skin (4). A CD4 assessment may be useful in HIV-infected individuals, as HIV infection depletes intestinal CD4(+) T cells and has a strong association with the level of systemic CD4(+) T cell activation (5). Tumor infiltrating CD4 T cells may also be a prognostic factor for the strategy of early antitumor immunity (6).


Concentrate, Predilute


0.1 ml, 1.0 ml, 6.0 ml

Intended Use



Mouse Monoclonal






Prokaryotic recombinant protein corresponding to the external domain of the CD4 molecule


Cell Membrane

Positive Control


1. Leong A S-Y, Cooper K and Leong F J W-M eds. Manual of diagnostic antibodies
for immunohistology, second edition 2003. Greenwich Medical Media Ltd: p. 65-6.
2. Izban KF, Hsi ED, Alkan S. Immunohistochemical analysis of mycosis fungoides on
paraffin-embedded tissue sections. Mod Pathol. 1998 Oct; 11(10):978-82.
3. Macon WR, Salhany KE. T-cell subset analysis of peripheral T-cell lymphomas by
paraffin section immunohistology and correlation of CD4/CD8 results with flow
cytometry. Am J Clin Pathol. 1998 May; 109(5):610-7.
4. Uchiyama N, et al. CD2-, CD4+, CD56+ agranular natural killer cell lymphoma of
the skin. Am J Dermatopathol. 1998 Oct;20(5):513-7.
5. Gordon SN, et al. Disruption of intestinal CD4+ T cell homeostasis is a key marker
of systemic CD4+ T cell activation in HIV-infected individuals. J Immunol. 2010 Nov
6. Rathore AS, et al. CD3+, CD4+ & CD8+ tumour infiltrating lymphocytes (TILs) are
predictors of favourable survival outcome in infiltrating ductal carcinoma of breast.
Indian J Med Res. 2014 Sep;140(3):361-9.
7. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22,
Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove
Azide Salts.”
8. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory
Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition
CLSI document M29-A4 Wayne, PA 2014.