Meet the Marker: CD54 (ICAM-1)

Cluster of Differentiation 54 (CD54), also known as Intercellular Adhesion Molecule 1 (ICAM-1), is a 90 kDa glycosylated transmembrane protein of the immunoglobulin superfamily. CD54 (ICAM-1) can play an important role in immunological synapse formation, T-cell activation, leukocyte migration, and numerous cellular immune responses.1 CD54 (ICAM-1) also interacts with integrin receptors on leukocytes, such as lymphocyte function-associated antigen-1 (LFA-1), to enhance cell-cell adhesion and promote immune cell recruitment and activation. Its multifaceted role in mediating leukocyte-endothelial interactions may demonstrate its importance in various physiological and pathological processes.

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